Capture Sphere

While equipped, for every enemy killed with a bomb, your bomb damage is increased by 5.

This relic doesn't have a limit to the bomb damage it can do. The technical limit is 2.14 billion bomb damage (it will crash the game) however it is impractical to kill 214 million enemies in a single run.

The damage increase from Capture Sphere doesn't pair with since it set's the bomb damage to a specific amount.